The main positives will be the advantage of being able to change gear whilst not pedalling and the removal of the rear freewheel - so a reduction in moving parts.
Possible disadvantages will depend on the rider, where and how you ride and potentially the particular bike, plus as stated the extra wear of the motor free wheel, though this is probably minimal.
The chain will be constantly in motion, so ultimately more wear on the chain, chainring, sprockets, derailleur.
An EMTB obviously has higher chain wear than a none E due to the extra force being applied for most riders. The force being applied by 100+kg's through a wheel when descending/accelerating at speed must be orders of magnitude higher !
Chain slap could be more of an issue with the chain moving whilst slapping - generally it won't be slapping as much when you're pedalling as when you're not pedalling.
Risk of the chain coming off will be higher for the same reasons so it will be important to make sure the clutch is set correctly and the guide might need adjustment.
There will be a higher chance of chain breakage and destruction of the derailleur/hanger from foreign objects entering the drive train. If you consider when you're riding up "branchy" terrain, you'll often stop pedalling momentarily to stop branches flying up and being pulled into the derailleur, locking it up and tearing it off - you won't be able to do that and whilst you're descending with branches flying everywhere, you're high speed automated derailleur destruction feed system will be active and effective !
Elevated risk of personal injury/unplanned dismounts. When descending, if you're quite an active rider and move your feet about, there's a chance you could move your heel/ankle into the chain line - which will be like a blunt chainsaw. Similarly, if your trousers or something else gets pulled into the chainring/chainguide it will stop the chain and in turn lock the rear wheel.