The range of voltages under discussion are probably all low enough for this to not be a concern but there are some disadvantages to higher voltages…
Higher voltage MOSFETs (in the BMS) typically have higher resistance when on and that creates more heat.
Tougher component spacing/clearance...
Some great stuff from @Rob Rides EMTB and @Bengy22, thank you for sharing your content and thoughts!
Yea, Ampace has an incredible pedigree and is the real deal, creating incredible cells like the JP30P1 18650 and JP50P1 21700.
Here’s my battery geek take on this new 50480 cell, its chemistry...